General Information

  • ID:  hor004160
  • Uniprot ID:  Q96RP3
  • Protein name:  Urocortin-2
  • Gene name:  UCN2
  • Organism:  Homo sapiens (Human)
  • Family:  Sauvagine/corticotropin-releasing factor/urotensin I family
  • Source:  Human
  • Expression:  human placenta decidua and fetal membranes
  • Disease:  Diseases associated with UCN2 include Anxiety and Body Mass Index Quantitative Trait Locus 11.
  • Comments:  NA
  • Taxonomy:  Homo (genus), Homininae (subfamily), Hominidae (family), Hominoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0001664 G protein-coupled receptor binding; GO:0005179 hormone activity; GO:0042562 hormone binding; GO:0051429 corticotropin-releasing hormone receptor binding; GO:0051431 corticotropin-releasing hormone receptor 2 binding
  • GO BP:  GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway; GO:0007586 digestion; GO:0009755 hormone-mediated signaling pathway; GO:0031669 cellular response to nutrient levels
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

  • Sequence:  IVLSLDVPIGLLQILLEQARARAAREQATTNARILARVGHC
  • Length:  41(72-112)
  • Propeptide:  MTRCALLLLMVLMLGRVLVVPVTPIPTFQLRPQNSPQTTPRPAASESPSAAPTWPWAAQSHCSPTRHPGSRIVLSLDVPIGLLQILLEQARARAAREQATTNARILARVGHC
  • Signal peptide:  MTRCALLLLMVLMLGRVLVVPV
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Suppresses food intake, delays gastric emptying and decreases heat-induced edema; might represent an endogenous ligand for maintaining homeostasis after stress;may play a role in the regulation of estradiol production throughout pregnancy thereby contribu
  • Mechanism:  Ucn 2 induced a central CRF(2)-mediated inhibition of gastric emptying involving sympathetic alpha(1)-adrenergic mechanisms
  • Cross BBB:  YES
  • Target:  CRHR2, CRHR1
  • Target Unid:  Q13324, P34998
  • IC50: NA
  • EC50: cAMP rCRF-R2-alpha:0.26nmol;cAMP mCRF-R2-beta:0.42nmol
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q03191-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-Q03191-F1.pdbhor004160_AF2.pdbhor004160_ESM.pdb

Physical Information

Mass: 516497 Formula: C194H338N62O55S
Absent amino acids: FKMWY Common amino acids: AL
pI: 10.33 Basic residues: 6
Polar residues: 7 Hydrophobic residues: 21
Hydrophobicity: 42.68 Boman Index: -5133
Half-Life: 20 hour Half-Life Yeast: 30 min
Half-Life E.Coli: >10 hour Aliphatic Index 142.93
Instability Index: 3338.78 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  16223946
  • Title:  Urocortin 2 Acts Centrally to Delay Gastric Emptying Through Sympathetic Pathways While CRF and Urocortin 1 Inhibitory Actions Are Vagal Dependent in Rats
  • PubMed ID:  19417223
  • Title:  Urocortin 2 Stimulates Estradiol Secretion From Cultured Human Placental Cells: An Effect Mediated
  • PubMed ID:  22000474
  • Title:  
  • PubMed ID:  11416224
  • Title: